Staff Profile

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Dr. Xavier Chee

Senior Lecturer
B.Sc in Chemistry (Hons), Ph.D. (Cantab)

Faculty of Engineering, Computing and Science

Office No:+60 82 260 049
Fax No:+60 82 260 813
Room No: E619, Building G, FECS
Email: xchee@swinburne.edu.my
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Xavier received his BSc in Chemistry (Hons) from the Department of Chemistry, Imperial College London, UK in 2014. Subsequently, he did his PhD with Dr Taufiq Rahman in the Department of Pharmacology, University of Cambridge, UK focusing on finding new antibiotics using computational drug discovery methods. After completing his PhD in 2017, Xavier had decided to take break from research and went to teach Chemistry in an international school in his hometown Sibu. Later, he joined the School of Chemical Engineering & Science, Swinburne University of Technology Sarawak as a lecturer in 2019.

His research interests include using computational drug discovery methods, molecular dynamics simulation and machine learning to find new chemicals compounds against different drug targets to treat diseases.  Nowadays, his focus is on designing dual-inhibitors against various therapeutic targets.

Research Interests

  • Molecular dynamic simulation
  • Protein dynamics
  • Small molecule inhibitors
  • Rationale drug design
  • Machine learning

PhD / Master by Research Opportunities

Prospective higher-degree research candidates are highly welcome to enquire about research opportunities with Dr Xavier Chee in the listed research areas. For any inquiries, please e-mail xchee@swinburne.edu.my for more information.

Research Grants

  • Machine learning-driven discovery of EBNA1 inhibitors against Epstein-barr Virus in nasopharyngeal cancer; Xavier Chee (PI); MAKNA Cancer Research Award by National Cancer Council Malaysia, Award Amount, MYR29,825 (2 years); 2021-2023
  • Machine learning-guided design of dual-action MgrA/AgrA inhibitors to suppress aureus virulence and pathogenesis, Award Amount, RM250,000 (3 years); 2021-2024
  • Virtual screening and discovery of small molecule inhibitors of Staphylococcal quorum sensing as a strategy to treat diabetic foot infection; Xavier Chee (PI); Swinburne Strategic Research Grant by Swinburne Sarawak, Award Amount, MYR24,940 (3 years); 2019-2022


  • Books and book chapters Rahman, T. & Chee, X. Book Chapter 3 of Small molecule transcription factor inhibitors in oncology. 55-75 (CPI Group (UK) Ltd,2019)
  • Journal paper Abdelhamid, Y, et al. Evolutionary plasticity in the allosteric regulator binding site of a bacterial pyruvate kinase. Journal of Biological Chemistry (2019)
  • Journal paperChandran, A, et al. Exploration of inositol 1,4,5-trisphosphate (IP3) regulated dynamics of N-terminal domain of IP3 receptor reveals early phase molecular events during receptor activation. Scientific Reports (2019)
  • Journal paper McVey, A. et al. Structural and Functional Characterization of Malate Synthase G from Opportunistic Pathogen Pseudomonas aeruginosa. Biochemistry (2017).