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Staff Profile

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Associate Professor Peter Morin Nissom

Associate Professor & Head of School - Science
BSc (Hons) UM, Dphil (Oxf.)

Faculty of Engineering, Computing and Science

Office No:+60 82 260 939
Fax No:+60 82 260 813
Room No: E301, Building E, FECS
Email: pmorin@swinburne.edu.my

Biography

Peter obtained his B.Sc (Hons) in Microbiology from University of Malaya in 1992 and a Doctor of Philosophy (D.Phil) in Biochemistry/Molecular Biology from Exeter College, University of Oxford in 1998. He was a Research Scientist, and Head of Microarray Group with A-Star Bioprocessing Technology Institute in Singapore (2001 to 2010) prior to joining the Faculty of Engineering, Computing and Science, Swinburne University of Technology Sarawak Campus. His areas of expertise are industrial and environmental microbiology, molecular and cellular biology, system biology and genomics with specialization in high throughput gene expression profiling using DNA microarray and Next-Gen sequencing technologies. He has a H-index of 16 and have published journal papers and book chapters, in the subject area of genomics and gene expression analysis. His current research interest is in biocontrol of animal and plant pathogens, as well as applications of Microbially Induced Calcite Precipitation (MICP) to potential road construction, in collaboration with School of Engineering.

Citation records and profile may be accessed at here

Research Interests

  • Development of biocontrol agents against plant and animal pathogens
  • Industrial Microorganisms for bioindustry
  • Sequencing and analysis of Chinese hamster transcriptome.
  • Development of microarray resources for Chinese hamster ovary (CHO) cells.
  • Expression profiling of industrially important mammalian cell lines using microarray and next generation sequencing technology.
  • Systems biology: Identifying biomarkers from genomics and proteomics data.
  • Targeting miRNA in CHO cells as a method to developing highly productive and robust cell lines
  • Biomarkers discovery for cancer and immune disorders.
  • Exploring miRNAs as potential therapeutics targets.

Current Research interest

  • Development of miRNA as biomarkers for early detection of cancer and the use thereafter as biotherapeutics;
  • Identifying microorganisms from unexplored environment as potential biocontrol agents against plant and animal pathogens;
One of our current research effort at Swinburne Sarawak is a collaborative effort involving SBC (Sarawak Biodiversity Centre). We have successfully isolated new Muscodor-like fungi from Borneo, Sarawak, Malaysia and evaluation of their potential use as biocontrol agents against Ganoderma boninense is ongoing. This project was a Ph.D thesis undertaken by Noreha Mahidi, who is a senior scientist with SBC.

Professional Memberships

  • Malaysian Peat Society
  • International Peat Society
  • Society for Industrial Microbiology & Biotechnology
  • American Society for Biochemistry and Molecular Biology
  • Society for Biochemical Engineers

Technical expertise and essential skills

  • Hands-on experience and sound knowledge of gene cloning and expression in mammalian cells.
  • Hands-on technical experience and knowledge of library constructions for cDNA, genomic and small RNA libraries
    1. Normalization of cDNA libraries
    2. Construction of phage libraries
    3. Construction of libraries for Roche 454 and Illumina Next Generation sequencing technologies
    4. Construction of small RNA libraries for Illumina and ABI SOLID sequencing
  • Sound knowledge of, and practical experience in data analysis, assembly and annotation of sequence data generated by next generation sequencers.
  • Application of gene and protein microarray, real time PCR, proteomics, next generation sequencing (Roche 454, Illumina, ABI Solid), to the discovery of biomarkers and gene targets
  • Plant tissue culture and Mammalian cell culture.

Achievements and awards

  • Founding member of Consortium for CHO Genomics
  • Sequenced the Chinese hamster ovary (CHO) transcriptome and developed Affymetrix CHO microarray

PhD/Master by Research Opportunities

NameDegreeArea of ResearchStart yearRole
Nurnajwanie SenianPhDBiocement2017Associate Supervisor
Stanley HoMScBiofertilizers2016Associate Supervisor
WendyMScBiofertilizers2016Associate Supervisor
Alan ChuaMScBiofertilizers2014Associate Supervisor
Kong Ee LingMScCancer2014Associate Supervisor
Lee Boon KiatMScCancer2014Associate Supervisor
Hasina MkwataMScBiocontrol2014Coordinating Supervisor
Armstrong Ighodalo Omoregie PhDBiocements2017Coordinating Supervisor
John SabangPhDFungi interactions in soil fertility2013Coordinating Supervisor
  • Publications

Publications

  • Book and book chapter Peter Morin Nissom and Robin Philp (2007) Genomics and proteomics of chinese hamster ovary (CHO) cells, p. 49-68. In Systems Biology, Mohamed Al-Rubeai and Martin Fussenegger (Eds.), Cell Engineering Vol 5, Springer, Holland.
  • Book and book chapter K. Wlaschin, W.S. Hu, A. Sanny, K.S. Tan, P.M. Nissom, P.F. Ong, A. Rink, Wong, T.K.K, R.J. Philip, B. Cham, C.F. Wong, K.M. Lim and M. Yap (2003) Genomic Exploration on Chinese Hamster Ovary Cells, p. 23-29. In Proceedings of the 18th ESACT Meeting (Granada) – Animal Cell Technology Meets Genomics, Francesc Godia and Martin Fussenegger (Eds.), Springer, Holland.
  • Book and book chapter Danny C. F. Wong, C. K. Heng, Kathy T. K. Wong, Peter M. Nissom, and Miranda G. S. Yap (2004) Elucidating apoptotic cell death in CHO cell batch & fed-batch cultures, p. 61-66. In Proceedings of the Seventeenth Annual Meeting of the Japanese Association for Animal Cell Technology (JAACT), Iijima, Shinji; Nishijima, Ken-ichi (Eds.) Animal Cell Technology: Basic & Applied Aspects, vol. 14, Springer, Holland
  • Book and book chapter Yih Yean Lee, Kathy Wong, Peter Morin Nissom, and Miranda G. S. Yap (2004) Transcriptional profiling of batch and fed-batch protein-free 293-HEK cultures using DNA microarray, p. 73-80. In Proceedings of the Seventeenth Annual Meeting of the Japanese Association for Animal Cell Technology (JAACT), Iijima, Shinji; Nishijima, Ken-ichi (Eds.) Animal Cell Technology: Basic & Applied Aspects, vol. 14, Springer, Holland
  • Journal paper Omoregie, A. I., Khoshdelnezamiha, G., Senian, N., Ong, D. E. L., and Nissom, P. M. 2017. ‘Experimental optimisation of various cultural conditions on urease activity for isolated Sporosarcina pasteurii strains and evaluation of their biocement potentials,’ Ecological Engineering,109, Part A, 65-75 (11 pages). (https://doi.org/10.1016/j.ecoleng.2017.09.012); Journal Impact Factor (2016): 2.914.
  • Journal paper Omoregie, A. I., Khoshdelnezamiha, G., Ong, D. E. L., & Nissom, P. M. 2017, ‘An Improvement of Microbial Induced Carbonate Precipitation (MICP) Using A Sustainable Treatment Technique,’ International Journal of Service Management and Sustainability,’ 2(1), 17-31 (15 pages). (http://www.sarawak.uitm.edu.my/ijsms/ijsms_vol_2/No2_MICP_Armstrong.pdf)
  • Journal paper Armstrong Ighodalo Omoregie, Nurnajwani Senian, Phua Ye Li, Ngu Lock Hei, Dominic Ong Ek Leong, Irine Runnie Henry Ginjom and Peter Morin Nissom (2016). Ureolytic bacteria isolated from Sarawak limestone caves show high urease enzyme activity comparable to that of Sporosarcina pasteurii (DSM 33). Malaysian Journal of Microbiology 12(6): 463-470.
  • Journal paper Armstrong Ighodalo Omoregie, Nurnajwani Senian, Phua Ye Li, Ngu Lock Hei, Dominic Ong Ek Leong, Irine Runnie Henry Ginjom & Peter Morin Nissom (2016). Screening for Urease-Producing Bacteria from Limestone Caves of Sarawak. Borneo Journal of Resource Science and Technology (2016) 6(1): 37-45
  • Journal paper Kong Ee Ling, Lee Boon Kiat, Michelle, Irine Ginjom, Peter Morin Nissom (2015) DNA damage inhibitory effect and phytochemicals or fermented red brown rice extract. Asian Pacific Journal of Tropical Disease, Vol.5, Issue 9, pp. 732-736
  • Journal paper Anbalagan D, Yap G, Yuan Y, Pandey VK, Lau WH, Arora S, Bist P, Wong JS, Sethi G,Nissom PM, Lobie PE, Lim LH. Annexin-A1 regulates microRNA-26b* and microRNA-562 to directly target NF-κB and angiogenesis in breast cancer cells. PLoS One. 2014 Dec 23;9(12):e114507. doi: 10.1371/journal.pone.0114507. 
  • Journal paper Yi Ling Chia, Chew Har Ng, Philip Lashmit, Kai Ling Chu, Qiao Jing Lew, Jia Pei Ho, Hsueh Lee Lim, Peter Morin Nissom, Mark F. Stinski, and Sheng-Hao Chao. Inhibition of human cytomegalovirus replication by overexpression of CREB1 Antiviral Research, 2014: 102: 11-22
  • Journal paper Johnson KC, Jacob NM, Nissom PM, Hackl M, Lee LH, Yap M, Hu WS. Conserved microRNAs in Chinese hamster ovary cell lines. Biotechnol Bioeng. 2011. Feb;108(2):475-80. PubMed PMID: 20830683.
  • Journal paper Wong NS, Wati L, Nissom PM, Feng HT, Lee MM, Yap MG. An investigation of intracellular glycosylation activities in CHO cells: effects of nucleotide sugar precursor feeding. Biotechnol Bioeng. 2010 Oct 1;107(2):321-36.
  • Journal paper Dave SW Ow, Denis YX Lim, Peter M Nissom, Andrea Camattari and Victor VT Wong. Co-expression of Skp and FkpA chaperones alters the global expression of stress response and other metabolic genes during scFvD1.3 production Microb Cell Fact. 2010 Apr 13;9(1):22.
  • Journal paper Kantardjieff A, Nissom PM, Chuah SH, Yusufi F, Jacob NM, Mulukutla BC, Yap M, Hu WS. Developing genomic platforms for Chinese hamster ovary cells. Biotechnol Adv. 2009 Nov-Dec;27(6):1028-35.
  • Journal paper Koh TC, Lee YY, Chang SQ, Nissom PM. Identification and expression analysis of miRNAs during batch culture of HEK-293 cells. J Biotechnol. 2009 Mar 25;140(3-4):149-55.
  • Journal paper Yee JC, Wlaschin KF, Chuah SH, Nissom PM, Hu WS. Quality assessment of cross-species hybridization of CHO transcriptome on a mouse DNA oligo microarray. Biotechnol Bioeng. 2008 Dec 15;101(6):1359-65.
  • Journal paper Chan KK, Wu SM, Nissom PM, Oh SK, Choo AB. Generation of high-level stable transgene expressing human embryonic stem cell lines using Chinese hamster elongation factor-1 alpha promoter system. Stem Cells Dev. 2008 Aug;17(4):825-36.
  • Journal paper Nissom, P.M. (2007) Specific detection of residual CHO host cell DNA by real time PCR. Biologicals 35 (3): 211-215
  • Journal paper Ow DS, Lee RM, Nissom PM, Philp R, Oh SK, Yap MG. (2007) Inactivating FruR global regulator in plasmid-bearing Escherichia coli alters metabolic gene expression and improves growth rate. J Biotechnol. 131(3):261-9.
  • Journal paper De Leon Gatti M, Wlaschin KF, Nissom PM, Yap MGS and Hu W-S. (2007) Comparative transcriptional analysis of mouse hybridoma and recombinant Chinese hamster ovary cells undergoing butyrate treatment. Journal of Biosciences and Bioengineering 103 (1):82-91
  • Journal paper Lee YY, Wong TKK, Nissom PM, Wong DCF and Yap MGS (2007) Transcriptional profiling of batch and fed-batch protein-free 293-HEK cultures. Metabolic Engineering 9(1): 52-67
  • Journal paper Chua SW, Vijayakumar P, Nissom PM, Chan YL, Li B, Wong VVT and Yang H (2006) A novel normalisation method for effective removal of systematic variation in microarray data. Nucleic Acids Research 34(5):e38
  • Journal paper Nissom PM, Lo SL, Lo JCY, Lim JWE, Ou K, Liang CMY, Seow TK and Chung MCM (2006) Hcc-2, a novel mammalian ER thioredoxin that is differentially expressed in hepatocellular carcinoma. FEBS Letters 580 (9): 2216 – 2226
  • Journal paper Wong, VVT, Nissom, PM, Sim, SL, Yeo, J, Chuah, SH, Yap, MGS (2006) Zinc as an Insulin Replacement in Hybridoma Cultures. Biotechnol Bioeng 93 (3): 553 – 563
  • Journal paper Yeo JHM, Lo JCY, Nissom PM and Wong VVT (2006) Glutamine or glucose starvation in hybridoma induces death receptor and mitochondrial apoptosis pathways. Biotechnology Letters 28 (18): 1445-1452
  • Journal paper Nissom PM, Sanny A, Kok YJ, Yeo TH, Chuah SH, Tan KS, Lee YY, Wong TKK, Hu W-S, Yap MGS and Philp R (2006) Transcriptome and proteome profiling to understand the biology of high productivity CHO cells. Molecular Biotechnology 34 (2): 125-140
  • Journal paper Wong CFD, Wong TKK, Lee YY, Heng CK, Nissom PM and Yap MGS (2006) Transcriptional profiling of apoptotic pathways in batch and fed-batch CHO cell cultures. Biotechnology and Bioengineering 94 (2): 373 – 382
  • Journal paper Wong, KTK, Lee, YY, Brusic, V, Tan, J, Yap, MGS and Nissom, PM (2005) Elevation of gamma-glutamyltransferase activity in 293 HEK cells constitutively expressing antisense glutaminase mRNA. Metabolic Eng. 7 (5-6): 375 – 383
  • Journal paper Wlaschin, KF, Nissom, PM, Gatti, MD, Ong, PF, Arleen, S, Tan, KS, Rink, A, Cham, B, Wong, K, Yap, M and Hu, WS (2005) EST sequencing for gene discovery in Chinese hamster ovary cells. Biotechnol Bioeng. 91(5): 592-606
  • Journal paper Wong DC, Wong KT, Nissom PM, Heng CK, Yap MG. Targeting early apoptotic genes in batch and fed-batch CHO cell cultures. Biotechnol Bioeng. 2006 Oct 20;95(3):350-61.
  • Journal paper Wlaschin KF, Nissom PM, Gatti Mde L, Ong PF, Arleen S, Tan KS, Rink A, Cham B, Wong K, Yap M, Hu WS. EST sequencing for gene discovery in Chinese hamster ovary cells. Biotechnol Bioeng. 2005 Sep 5;91(5):592-606.
  • Journal paper Dave Siak-Wei Ow, Peter Morin Nissom, Robin Philp, Steve Kah-Weng Oh and Miranda Gek-Sim Yap (2005) Global transcriptional analysis of metabolic burden due to plasmid maintenance in Escherichia coli DH5a during batch fermentation. Enzyme Microbial Tech.
  • Conference paper Boon Kiat Lee, Reagan Entigu Linton, Peter Morin Nissom and Paul Matthew Neilsen. Investigating The Influence Of Epstein-Barr Virus On The P53 Pathway In Nasopharyngeal Carcinoma. 3rd Advancement Research on Biotechnology, and Biofuels International Conference, Nov 20-23, 2017, Medan, Sumatera, Indonesia
  • Conference paper Holed Juboi, Siawsan Hwang, Tiong Chia Yeo, Peter Morin Nissom. A Marine-Derived Rare Actinomycetes, Plantactinospora Sp, KBS50 As A Promising Source Of Discovery Of New Bioactive Natural Product Compound. International Conference on Natural Products, 15-16 March, Damai Laut, Perak, Malaysia 2017
  • Conference paper AI Omoregie, GIR Henry, ODE Leong, PM Nissom. Cross-Disciplinary Research: Developing Biocement Applications Using Locally Isolated Ureolytic Bacteria. 4th Borneo Research Education Conference, UITM, Kota Samarahan, Sarawak, Malaysia Aug 17-18, 2016
  • Conference paper Nurnajwani Senian, Armstrong Ighodalo Omoregie, Peter Morin Nissom, Ngu Lock Hei, Dominic Ong Ek Leong. Identification Of Locally Found Bacteria For Potential Use In Ground Improvement Works By Microbially Induced Calcite Precipitation (MICP) Technique. Proceedings of the 19th International Conference on Transformative Science and Engineering, Business and Social Innovation”, A.H. Dogru, S. Suh; Society for Design and Process Science, Texas; pp 261 – 266.
  • Conference paper Nurnajwani Senian, Ghazaleh Khoshdelnezamiha, Armstrong Ighodalo Omoregie, Dominic Ong Ek Leong, Ngu Lock Hei, Peter Morin Nissom, Irine Runnie Henry Ginjom. Development of Bio-Pavers with Microbial Induced Calcite Precipitation Technique Using Sporosarcina pasteurii. Proceedings of the 19th Southeast Asian Geotechnical Conference & 2nd AGSSEA Conference”, S.W. Chan, T.A. Ooi, W.H. Ting (eds.); Malaysia Geotechnical Society, Malaysia; pp. 327 – 331. 978-983-40616-4-7
  • Conference paper Hasina Mohammed Mkwata, Lee Tung Tan, and Peter Morin Nissom. Assessing The Diversity Of Viruses In Soils Obtained From Limestone Caves. Proceedings of the 15th International Peat Congress, At Kuching, Sarawak, Malaysia, 15-19 August 2016, pg 156-160
  • Conference paper Phua Ye Li, Armstring Lghodalo Omoregie, Dominic Ong, Ngu Lock Hei, Peter Morin Nissom, Irine Runnie Henry Ginjom. Ground improvement via Micobial-Induced Calcite Precipitation using push-pull injection system. 19th Southeast Asian Geotechnical Conference & 2nd AGSSEA Conference”, Kuala Lumpur, Malaysia, 31 May-3 June 2016; pp. 495-498. 978-983-40616-4-7
  • Conference paper Omoregie, AI, Ginjom, IRH, Leong, DOE, & Nissom, PM, 2016, ‘Cross-Disciplinary Research: Developing Biocement Applications Using Locally Isolated Ureolytic Bacteria’, Proceedings of the 4th Borneo Research Education Conference, Universiti Teknologi Mara, pp. 1-8. ISBN: 978-967-0828-10-7
  • Conference paper Omoregie, AI, Senian, N, Li, PY, Hei, NL, Leong, DOE, Ginjom, IRH & Nissom, PM. Characterisation of Urease Producing Bacteria from Sarawak Caves and their Role in Calcite Precipitation. International Congress of the Malaysian Society for Microbiology (ICMSM2015)”, Penang, Malaysia, 7-10 December 2015; pp. 16-21. 9789839987362
  • Conference paper Wen Loong Chan, Moritz Müller, Irine Runnie Ginjom, John Sabang, Lee Tung Daniel Tan and Peter Morin Nissom. Exploring Growth Enhancing Rhizospheric Microorganisms For Silviculture Of Eucalyptus Pellita. 33rd Symposium of The Malaysian Society For Microbiology 2016, Ramada Plaza, Melaka, Malaysia, 14-17 December 2016. pg 231
  • Conference paper Alan Yee Quan Chua, Moritz Müller, Irine Runnie Ginjom, John Sabang, Peter Morin Nissom and Lee Tung Tan. Exploring Growth Enhancing Rhizospheric Microorganisms For Silviculture Of Neolamarckia Cadamba. 33rd Symposium of The Malaysian Society For Microbiology 2016, Ramada Plaza, Melaka, Malaysia, 14-17 December 2016. pg 209
  • Conference paper AI Omoregie, N Senian, PY Li, NL Hei, DOE Leong, IRH Ginjom. Isolation And Characterisation Of Urease Producing Bacteria From Sarawak Caves And Their Role In Calcite Precipitation. International Congress of the Malaysian Society for Microbiology, 16-211 2015
  • Conference paper Nurnajwani Senian, Armstrong Ighodalo Omoregie, Peter Morin Nissom, Lock Hei Ngu and Dominic Ek-Leong Ong. Identification of locally found bacteria for potential use in ground improvement works by microbially induced calcite precipitation (MICP) technique. The 19th International Conference on Transformative Science & Engineering, Business & Social Innovation, Society for Design Process Science 2014, Kuching, Sarawak, Malaysia
  • Conference paper Noreha Mahedi, Moritz Mueller, Charlie Yeo, Clem Kuek, Peter M Nissom. Isolation of an endophytic fungus producing volatile anti-Ganoderma compounds: potential biological control agent for Ganoderma boninense. British Mycological Society (BMS) Meeting 2012 -Fungal Interactions, University Alicante, Spain