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Swinburne University of Technology Sarawak Campus

Associate Professor Dr. Hwang Siaw San

Associate Professor & Head of School - Chemical Engineering and Science
PhD (Molecular Biology, UNIMAS)

Faculty of Engineering, Computing and Science

Office No:+60 82 260 825
Fax No:+60 82 260 865
Room No: E302, Building E, FECS
Email: shwang@swinburne.edu.my

Biography

S.S. Hwang joined Swinburne University of Technology Sarawak Campus (SUTS) in 2010 as a lecturer in Biochemistry and Molecular Biology. Hwang received her PhD in Molecular Biology and her dissertation research investigated genes involved in the starch biosynthesis pathway of sago palm (Metroxylon sagu). Her early research was focused on defense response genes from oil palm (Elaies guineensis Jacq.), when she attached to Malaysian Palm Oil Board (MPOB) for her MSc. project. Prior to joining SUTS, Hwang was a researcher at the Agrobiotech Branch of Agriculture Research Center (ARC), Department of Agriculture Sarawak. Her research experiences include molecular biology of disease resistance in crops and development of molecular marker for crops breeding programs. Her current research projects focus on biomedical sciences including biomarkers, pre-clinical and clinical studies in cardiovascular disease and cancers. She also involves in the studies of nutraceuticals development from natural products such as Sarawak local rice extracts for cardioprotection, anti-cancer and anti-diabetic properties; transcriptome analysis and molecular mechanisms in disease resistance and fruit ripening in Sarawak black pepper

Research Interests

  • Biomarkers for atherosclerosis and cardiovascular disease.
  • Natural products for antioxidants, anticancer, antidiabetics properties.
  • Cardiovascular drug pharmacogenomics
  • Applications of Next-generation sequencing (NGS) in crop improvement and breeding
  • Molecular biology of stress tolerance and disease resistance in plants

PhD/Master by Research Opportunity

Potential research higher degree candidates are welcome to enquire about postgraduate opportunities in the following areas/ projects:

  1. Role of antioxidants in prevention of oxidative stress-induced apoptosis in cardiomyocytes
  2. The studies of differentiation and proliferation of stem cells into functional cardiomyocytes.
  3. Pharmacogenomics in cardiovascular disease: the potential of biomarkers in drug therapy

Please contact Dr. Hwang SS for more information on the above topics.

PhD/Master by Research Opportunities

NameDegreeArea of ResearchStart yearRole
Diana Choo Chung YingPhDNatural products- biological activity against nasopharyngeal cancer cells (NPC)2017Co-supervisor
Nur DiyanaMScBioactivities in food extracts2017Co-supervisor
Khew Choy YuenPhDTranscriptomic analyses and molecular characterization of flower and fruit development in black pepper2016Coordinating Supervisor
Lau Ee TiingPhDTranscriptome and molecular characterization of pepper defense genes2016Coordinating Supervisor
Vivian LeeMScSerum biomarkers in association with coronary artery calcification2015Coordinating Supervisor
Jong Siu MeiPhDLeucocytes telomere length in acute myocardial infarction2015Co-supervisor
Reagan Entingu LintonPhDPotential Treatments for Nasopharyngeal cancer2015Co-supervisor

Research grant

SUTS Top Down StraDG Grant/2014
Title of Project: Physiological, Biochemical and Gene Expression Study of Abiotic Stress and Tolerance in Local Rice Varieties of Sarawak

Swinburne Melbourne-Sarawak Research Collaboration Scheme Grant 2013
Title of project: Testing the nutraceutical effects of vitamin E components isolated from rice and barley in a model cell line, for cardiovascular health benefits.

Swinburne Sarawak Research Grant 1/2013
Title of Project: Extraction and Antioxidant Activity Studies of Tocotrienols and γ-oryzanol from Sarawak Local Rice Varieties

Swinburne Sarawak Seed Grant Scheme 2012
Title of project: Cytochrome P4502C19 (*2, *3, *17) Allelic Variant, Platelet Aggregation and Clinical Outcome in Clopidogrel-treated Patients Prior to Coronary Angiography.

External Grant: Ministry of Health Malaysia (MOH) 2013. A collaboration project with Sarawak General Hospital Heart Center.
Title of project: Plaque Instability Markers as a Possible Multimarker Approach in Defining and Monitoring an Unstable Angina Event (Multimarker-Unstable Angina)

External Grant: Ministry of Health Malaysia (MOH) 2012. A collaboration project with Sarawak General Hospital Heart Center.
Title of project: Thrombin and Activated Coagulation Factor X as Biomarkers to Identify Poor Respondents towards Warfarin among Multiethnic Malaysian patients – A Pilot Study.

External Grant: Ministry of Health Malaysia (MOH) 2010. A collaboration project with Sarawak General Hospital Heart Center.
Title of project: Platelet reactivity to aspirin and clopidogrel in patients undergoing coronary angiography: a multiethnic study in Malaysia population.

  • Publications

Publications

  • Journal paper Yeo, B.P.H., Foong, L.C., Tam, S.M., Lee, V., & Hwang, S.S. 2018. Gene Isolation Using Degenerate Primers Targeting Protein Motifs: A Laboratory Exercise. Biochem Mol Biol Educ. Vol. 46(1):47-53. doi: 10.1002/bmb.21089.
  • Journal paper Yeo, B.P.H., Bhave, M. & Hwang, S.S. 2017. Effects of acute salt stress on modulation of gene expression in a Malaysian salt-tolerant indigenous rice variety, Bajong. J Plant Res, Vol. 131, Issue 1, pp 191–202. doi: 10.1007/s10265-017-0977-6.
  • Journal paper Ho, B.K., Ngaini, Z., Neilsen, P.M., Hwang, S.S., Linton, R.E., Kong, E.L. & Lee, B.K. 2017. Synthesis and Anticancer Activities of 4-[(Halophenyl)diazenyl]phenol and 4-[(Halophenyl)diazenyl]phenyl Aspirinate Derivatives against Nasopharyngeal Cancer Cell Lines. Journal of Chemistry. Volume 2017, Article ID 6760413, 7 pages. https://doi.org/10.1155/2017/6760413.
  • Journal paper Tan, X.W., Bhave, M., Fong, A.Y.Y., Matsuura, E., Kobayashi, K., Shen, L.H. & Hwang, S.S. 2016. Cytoprotective and Cytotoxic Effects of Rice Bran Extracts in Rat H9c2(2-1) Cardiomyocytes. Oxidative Medicine and Cellular Longevity, Vol. 2016, 1-12.
  • Journal paper Lim, M.S.H., Anchah, L., Tiong, W.N., Hwang, S.S., Ong, T.K., Sim, K.H., Fong, A.Y.Y. 2014. Thrombin and FXa plasma concentration levels in patients with atrial fibrillation on long term warfarin therapy. Asean Heart Journal, Vol. 22, No. 1, 20– 29. ISSN: 2314-4551.
  • Journal paper Meijin, M., Tiong, W.N., Lai, L.Y.H., Bujang, M.A, Hwang, S.S., Ong, T.K. and Fong, A.Y.Y. 2013. CYP2C19 genotypes and their impact on clopidogrel responsiveness in percutaneous coronary intervention. International Journal of Clinical Pharmacy, DOI 10.1007/s11096-013-9783-y, ISSN 2210-7703.
  • Journal paper Tiong, W.N., Mejin, M., Fong, A.Y.Y., Wee, C.C., Lai, L.Y.H., Hwang, S.S., Bujang, M.A, Tiong, L.L. & Ong, T.K. 2013. Trends of Platelet Inhibition in Different Clopidogrel Pretreatment Patterns in Malaysian Patients Undergoing Elective Percutaneous Coronary Intervention. Med Journal of Malaysia, Vol. 68 (4): 326-331. 
  • Journal paper Tiong, W.N., Fong, A.Y.Y., Hwang, S.S., Wee, C.C., Mejin, M., Ong, T.K. 2012. Cytochrome P450 2C19 Polymorphism and Platelet Aggregation in Clopidogrel-treated Patients among Malaysian Multiethnic Population. Heart, 98: Suppl 2 (doi:10.1136/heartjnl-2012-302920v.4).
  • Journal paper Lau, E.T., Hwang, S.S., Eng, L. and Paulus, A.D. 2012. Cloning and characterization of Resistance Gene Analogues (RGAs) from Piper nigrum L. cv. Semongok Aman and Piper colubrinum Link. International Journal of Bioscience, Biochemistry and Bioinformatics, Vol. 2, No. 5.
  • Journal paper Tiong, W.N., Hwang, S.S., Fong, A.Y.Y., Wee, C.C., Lai, L.Y.H., Tiong, L.L., Chang, B.C. and Ong, T.K. 2012. The Influence of CYP2C19*2 and *3 Polymorphisms on the Platelet Aggregation in Malaysian Chinese and non-Chinese Population. European Heart Journal Volume 14, Issue suppl A.
  • Journal paper Tnah, L.H., Lee, C.T., Lee, S.L., Ng, K.S.K., Ng, C.H. and Hwang, S.S. 2011. Microsatellite Markers of an Important Medicinal Plant, Eurycoma Longifolia (Simaroubaceae), for DNA Profiling. American Journal of Botany, e1-e3.
  • Journal paper Salleh, M A, Lau, J.S.K, Jamel, B. and Hwang, S.S. 2004. Characterization of the starch biosynthesis pathway in sago palm: Isolation of genes coding for the starch synthase, ADP-glucose Pyrophosphorylase, starch branching enzyme and starch debranching enzyme. In Biotechnology for Sustainable Utilisation of Biological Resources in the Tropics (Seki, T, et al., eds.), 17:54-59.
  • Conference paper Adasuriya, I.A., Hwang, S.S. & Ginjom, I.R.H. 2017. Antioxidant and Cardio-protective Potentials of Selected Local Edible Plants. International Conference on Food Science and Nutrition 2017 (ICFSN 2017). The Pacific Sutera Hotel, Kota Kinabalu, Sabah, Malaysia. 25 – 26th October 2017.
  • Conference paper Khew, C.Y., Lai, P.S. & Hwang, S.S. 2017. De Novo Assembly of Fruit Transcriptome in Black Pepper (Piper nigrum L.). 12th Malaysia International Genetics Congress. Bangi-Putrajaya Hotel, Selangor, Malaysia. 25 – 27th September 2017.
  • Conference paper Lau, E.T., Khew, C.Y. & Hwang, S.S. 2017. De novo transcriptome sequencing of black pepper (Piper nigrum L.). 12th Malaysia International Genetics Congress. Bangi-Putrajaya Hotel, Selangor, Malaysia. 25 – 27th September 2017.
  • Conference paper Tan, X.W., Hwang, S.S. & Matsuura, E. 2017. Natural Ameliorative Biomaterial for Oxidative Stress and Inflammation. 20th International Conference of Mechanics in Medicine and Biology (ICMMB 2017). Melbourne, Australia. 24-25th May, 2017.
  • Conference paper Yeo, P.H., Bhave, M. & Hwang, S.S. 2016. De novo transcriptome assembly of Sarawak local rice variety and discovery of saline responsive genes. The 3rd Plant Genomic Congress Asia. Kuala Lumpur, Malaysia. 11-12th April, 2016.
  • Conference paper Tan, X.W., Bhave, M., Fong, A.Y.Y. & Hwang, S.S. 2015. Potential Cytoprotective Effects of Rice Bran Extracts against Oxidative Stress in Rat Cardiomyocytes. The Annual Conference of Life Science and Engineering. Osaka, Japan. 25-27th August, 2015.
  • Conference paper Tan, X.W., Hwang, S.S and Fong, A.Y.Y. 2014. The studies of antioxidant activities in Sarawak local rice varieties. The 2nd International Conference on Advances in Plant Science. 18-24th November, 2014, Four Points by Sheraton, Kuching, Sarawak, Malaysia. (Accepted).
  • Conference paper Foo, D.H.P., Lim, M.S.H., Anchah, L., Tiong, W.N., Hwang,S.S., Fong, A.Y.Y., Mejin, M., Chin, F.Y.Y. and Ong, T.K. 2014. Impact of gender on plasma thrombin levels in patients with atrial fibrillation on long term warfarin therapy. 20th ASEAN Federation of Cardiology Congress 2014. 12-15th June, 2014, Kuala Lumpur City Centre (KLCC), Malaysia.
  • Conference paper Chua, J.N., Hwang, S.S., Tiong, W.N., Lai, L.Y.H., Mejin, M., Tiong, .LL., Fong, A.Y.Y. and Ong, T.K. 2014. Prevalence of ABCB1 and CYP2C19 polymorphisms in clopidogrel-treated multi-ethnic Malaysian patients planned for percutaneous coronary intervention (PCI). 20th ASEAN Federation of Cardiology Congress 2014. 12-15th June, 2014, Kuala Lumpur City Centre (KLCC), Malaysia.
  • Conference paper Tan. S.K., Lim, M.S.H., Tiong, W.N., Kong, K.L., Mejin, M., Chin, F.Y.Y., Fong, A.Y.Y., Hwang, S.S., Gudum, H., Tay, S.P., Anchah, L. and Ong, T.K. Clinical outcomes for activated factor lla and Xa inhibition in long term warfarin treated population. “20th ASEAN Federation of Cardiology Congress 2014”, Kuala Lumpur, Malaysia, 12-15 June 2014, pp. 29.
  • Conference paper Lim, M.S.H., Anchah, L., Tiong, W.N., Chin, F.Y.Y., Mejin, M., Tiong, L.L., Kong, K.L., Hwang, S.S., Ong, T.K., Fong, A.Y.Y. 2014. The Relationship of Thrombin and Factor Xa with the Time in Therapeutic Range in Patients on Long Term Warfarin Therapy. World Congress of Cardiology 2014, 4-7th May, Melbourne, Australia.
  • Conference paper Chua,J.N., Tiong, W.N., Lai,L.Y.H., Mejin, M., Tiong, L.L., Ong, T.K., Fong, A.Y.Y. and Hwang, S.S. 2014. Association between ABCB1 and CYP2C19 polymorphisms with ADP-induced platelet aggregation in clopidogrel-treated multi-ethnic Malaysian patients. World Congress of Cardiology 2014, 4-7th May, Melbourne, Australia.
  • Conference paper Tan, X.W., Hwang, S.S., Fong, A.Y.Y, Ng, S.M. and Ginjom, I.R. 2014. Preliminary screening of γ-oryzanol content in local rice varieties of Sarawak. The 18th Biological Sciences Graduate Congress (BSGC), 6-8th January 2014, University of Malaya, Kuala Lumpur, Malaysia.
  • Conference paper Lim, M.S.H., Tiong, W.N., Anchah, L., Fong, A.Y.Y., Hwang, S.S. and Ong, T.K. 2013. The Association of VKORC1 (-1639 G>A) Polymorphism with Weekly Warfarin Dose Requirement and its Impact on Long Term Warfarin Therapy in Multiethnic Borneo Population. The 13th Asian Conference on Clinical Pharmacy. 13-15th September, 2013, Haiphong City, Vietnam.
  • Conference paper Hwang, S.S., Chua, J.N., Tiong, W.N., Fong, A.Y.Y., Lai, L.Y.H., Tiong, L.L. and Ong, T.K. 2013. Multi-ethnic distribution of ABCB1 C3435T polymorphism and its association with ADP-induced platelet aggregation on patients receiving clopidogrel treatment. National Heart Association Malaysia Annual Scientific Meeting 2013.
  • Conference paper Chua, J.N., Tiong, W.N., Fong, A.Y.Y., Lai, L.Y.H., Tiong, L.L., Hwang, S.S. and Ong, T.K. 2013. Distribution of the CYP2C19*17 allele in multi-ethnic Malaysian patients with coronary artery disease planned for percutaneous coronary intervention. National Heart Association Malaysia Annual Scientific Meeting 2013.
  • Conference paper Tiong, W.N., Hwang, S.S., Lai, L.Y.H., Mejin, M., Tiong, L.L., Chua, J.N., Fong, A.Y.Y. and Ong, T.K. 2013. CYP2C19 variant, platelet aggregation, drug level and clinical outcome in clopidogrel pre-treated patients planned for percutaneous coronary intervention. National Heart Association Malaysia Annual Scientific Meeting 2013.
  • Conference paper Gudum, H., Tiong, W.N., Lim, M.S.H., Tay, S.P., Hwang, S.S., Fong, A.Y.Y., Ong, T.K. and Anchah, L. 2013. PIVKA-II can be an ideal marker for monitoring the therapeutic efficacy of warfarin on atrial fibrilation patients. National Heart Association Malaysia Annual Scientific Meeting 2013.
  • Conference paper Anchah, L., Tiong, W.N., Lim, M.S.H., Hwang, S.S., Mejin, M., Kong, K.L., Gudum, H.R., Fong, A.Y.Y., Tan, S.K. and Ong, T.K. 2013. Relation of Plasma Thrombin Concentration in Patients with Atrial Fibrillation to Differences in Warfarin Anticoagulation Dosing: A Prospective Single Centre Study. National Heart Association Malaysia Annual Scientific Meeting 2013.
  • Conference paper Lim, M.S.H., Tiong, W.N., Fong, A.Y.Y., Hwang, S.S., Kong, K.L., Mejin, M., Chin, F.Y.Y., Gudum, H.R., Tay, S.P., Ong, T.K. and Anchah, L. 2013. The prevalence of VKORC1 (-1639 G>A) polymorphism and its association with weekly warfarin dose requirement in multiethnic Sarawak population with atrial fibrillation. National Heart Association Malaysia Annual Scientific Meeting 2013.
  • Conference paper Tan, S.K., Lim, M.S.H., Tiong, W.N., Kong, K.L., Mejin, M., Chin, F.Y.Y., Fong, A.Y.Y., Hwang, S.S., Gudum, H.R., Tay, S.P., Anchah, L. and Ong, T.K. 2013. Clinical outcomes for activated factor IIa and Xa inhibition in long term warfarin treated population. National Heart Association Malaysia Annual Scientific Meeting 2013.
  • Conference paper Tiong, W.N., Fong, A.Y.Y., Hwang, S.S., Wee, C.C., Mejin, M., Ong, T.K. 2012. Cytochrome P450 2C19 Polymorphism and Platelet Aggregation in Clopidogrel-treated Patients among Malaysian Multiethnic Population. 23rd Great Wall International Congress of Cardiology – Asia Pacific Heart Congress 2012, Beijing on 11th-14th October, 2012.
  • Conference paper Lau, E.T., Hwang, S.S., Eng, L. and Paulus, A.D. 2012. Cloning and characterization of Resistance Gene Analogues (RGAs) from Piper nigrum L. cv. Semongok Aman and Piper colubrinum Link. International Conference on Asia Agriculture and Animal– ICAAA 2012, Singapore on 23th -25th July, 2012.
  • Conference paper Tiong, W.N., Hwang, S.S., Fong, A.Y.Y., Wee, C.C., Lai, L.Y.H., Tiong, L.L., Chang, B.C. and Ong, T.K. The Influence of CYP2C19*2 and *3 Polymorphisms on the Platelet Aggregation in Malaysian Chinese and non-Chinese Population. International Congress of Cardiology (ICC) 2012. Hong Kong Convention and Exhibition Centre on 24th -26th February, 2012.
  • Conference paper Eng, L., Hwang, S.S. and Poili, E. 2011. Payaya Dieback in Tawau, Sabah. International Congress of the Malaysian Society of Microbiology 2011. Bayview Beach Resort, Penang on 8th-12th December, 2011.
  • Conference paper Lew, Y.L., Eng, L. and Hwang, S.S. 2011. Molecular characterization of Fusarium spp.isolates From infected plants in Sarawak. In Research Officers’ Progress Meeting 2011, Department of Agriculture Sarawak held at Four Points Hotel, Kuching on 5th-6th October, 2011.
  • Conference paper Yeo, P.H., Hwang, S.S., Eng, L., Paulus, A.D. and Lau, E.T. 2011. Cloning and Characterization of the NBS-LRR-Encoding Resistance Gene Analogues Family in Piper colubrinum. In Research Officers’ Progress Meeting 2011, Department of Agriculture Sarawak held at Four Points Hotel, Kuching on 5th-6th October, 2011.
  • Conference paper Eng, L., Hwang, S.S. and Poili, E. 2011. Etiology of papaya dieback in Tawau, Sabah. In Research Officers’ Progress Meeting 2011, Department of Agriculture Sarawak held at Four Points Hotel, Kuching on 5th-6th October, 2011.
  • Conference paper Yeo, P.H., Hwang, S.S., Eng, L., Paulus, A.D. and Lau, E.T. 2011. Molecular characterization of resistance gene analogs (RGAs) in Piper colubrinum. In 9th Malaysian Genetic Congress held at Pullman Hotel, Kuching on 28th-30th September, 2011.
  • Conference paper Hwang, S.S., Lau, C.Y. and Eng, L. 2009. Preliminary Studies on Genetic Relatedness Among Six Individual Durian Trees Using DNA Markers. In Research Officers’ Progress Meeting 2009, Department of Agriculture Sarawak held at Four Points Hotel, Kuching on 18-19 November 2009.
  • Conference paper Hwang, S.S, Paulus, A.D. and Eng, L. 2009. Cloning and Sequence Analyses of Resistance Gene Analogs (RGAs) from Piper colubrinum. In Research Officers’ Progress Meeting 2009, Department of Agriculture Sarawak held at Four Points Hotel, Kuching on 18-19 November 2009.
  • Conference paper Hwang, S.S and Salleh, M.A. 2005. Isolation of a Full-length cDNA Encoding Metal Chelating Gene, Metallothionein, from Sago Palm (Metroxylon sagu). In Proceeding of the International Conference on Natural Resources and Environmental Management (Lau, S. edited), pp.372-378.
  • Conference paper Hwang, S.S and Salleh, M.A. 2005. Isolation and Characterization of Starch Branching Enzymes I (SBEI) and Starch Branching Enzyme II (SBEII) from Sago Palm (Metroxylon sagu). In Proceeding of the International Conference on Natural Resources and Environmental Management (Lau, S. edited), pp.379-385.
  • Conference paper Hwang, S.S and Salleh, M.A. 2005. Isolation and Characterization of Soluble Starch Synthase and Starch Debranching Enzyme from Sago Palm (Metroxylon sagu). In Proceeding of the International Conference on Natural Resources and Environmental Management (Lau, S. edited), pp. 386-394.
  • Conference paper Salleh, M A, Lau, J.S.K, Jamel, B. and Hwang, S.S. 2004. Characterization of the starch biosynthesis pathway in sago palm: Isolation of genes coding for the starch synthase, ADP-glucose Pyrophosphorylase, starch branching enzyme and starch debranching enzyme. Biotechnology for Sustainable Utilization of Biological Resources in the Tropics (Seki, T, et al., eds.), 17:54-59.